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Analytical Laboratories - LCMS/MS

Liquid Chromatography–Tandem Mass Spectrometry (LC-MS/MS)

Auriga Research utilizes advanced LC-MS/MS technology for ultra-sensitive, high-precision analysis across pharmaceuticals, food, nutraceuticals, environmental science, and clinical diagnostics. Combining liquid chromatography and tandem mass spectrometry, LC-MS/MS detects complex compounds at trace levels, ensuring compliance with regulatory standards for safety, quality, and accurate identification of bioactive ingredients and contaminants.

New LCMS installed at Auriga

Why Choose LC-MS/MS?

Enhanced Sensitivity

LC-MS/MS offers ultra-trace level detection at parts-per-trillion (ppt) sensitivity, essential for quantifying trace-level analytes and rare contaminants.

Multi-Analyte Capacity

With multi-ion detection, LC-MS/MS efficiently analyzes multiple target compounds within complex matrices, supporting comprehensive profiling and regulatory compliance.

Optimized Sample Handling

LC-MS/MS minimizes sample preparation needs, efficiently processing complex matrices and saving significant time while maintaining high accuracy and reproducibility.

Key Services

LCMS/MS

Comprehensive LC-MS/MS Analysis

Auriga’s LC-MS/MS services provide high-accuracy compound analysis, ensuring quality, compliance, and safety across industries.

Key Offerings:

  • Targeted Impurity and Contaminant Analysis

     

  • Quantification of Bioactive Compounds

     

  • Multi-Residue Pesticide Testing

     

  • Pharmacokinetic Profiling

     

  • Trace-Level Mycotoxin Detection

Applications of LC-MS/MS

LCMS/MS
Pharmaceutical Industry

LC-MS/MS supports pharmaceutical R&D and quality control by detecting trace impurities and verifying drug composition.

  • Impurity Profiling: Identifies and quantifies impurities in active ingredients and drug formulations.
  • Drug Metabolite Analysis: Detects and quantifies metabolites for pharmacokinetic studies.
  • Quality Assurance: Ensures compliance with regulatory standards for drug purity and safety.

LCMS/MS
Food Industry

In food testing, LC-MS/MS provides high-sensitivity analysis of contaminants, additives, and residues.

  • Pesticide Residue Detection: Screens for multiple pesticide residues in food products.
  • Mycotoxin Analysis: Detects mycotoxins in grains, nuts, and cereals, ensuring food safety.

LCMS/MS
Nutraceutical Industry

LC-MS/MS is essential in nutraceutical testing to confirm purity, label claims, and safety compliance.

  • Active Compound Analysis: Quantifies bioactive compounds, supporting accuracy in labeling.
  • Heavy Metal Testing: Screens for contaminants to meet safety standards.
  • Adulterant Detection: Identifies harmful or unauthorized ingredients in nutraceutical products.

LCMS/MS
Environmental Testing

LC-MS/MS supports environmental protection efforts by detecting pollutants in soil, water, and air.

  • Water Contaminant Analysis: Measures trace contaminants in drinking and wastewater.
  • PFAS Detection: Identifies and quantifies PFAS compounds, meeting regulatory requirements for environmental safety.
  • Soil and Sediment Testing: Monitors pollutants in soil, essential for environmental monitoring.

LCMS/MS
Cosmetic and Personal Care

LC-MS/MS ensures cosmetics and personal care products are free from harmful contaminants, supporting safety and regulatory compliance.

  • Heavy Metal Detection: Screens for toxic metals like lead and mercury in cosmetics.
  • Fragrance Compound Analysis: Identifies and quantifies fragrance components in formulations.
  • Preservative Testing: Verifies preservative levels to ensure product stability.

LCMS/MS
Veterinary Testing

LC-MS/MS is used in veterinary testing to monitor drug residues and contaminants, ensuring animal health and food safety.

  • Antibiotic Residue Analysis: Detects antibiotics in animal products, meeting safety standards for human consumption.
  • Hormone Level Testing: Monitors hormone treatments in livestock for regulatory compliance.
  • Feed Contaminant Detection: Screens for contaminants in animal feed, supporting livestock health.

LCMS/MS

 

LCMS/MS

Advanced Testing Facilities:

Auriga Research’s LC-MS/MS labs feature state-of-the-art technology, designed to provide precise, ultra-trace detection for complex sample matrices.

  • High-Precision Instruments
    Our triple-quadrupole LC-MS/MS systems achieve sub-ppt detection, integrating collision-induced dissociation and advanced ionization to analyze complex samples with high specificity.

Automated Workflows
High-throughput auto-sampling and advanced data software automate compound identification and quantitation, ensuring reproducible, rapid results with minimized analyst intervention.

LCMS/MS

 

LCMS/MS

Recent Methodologies:

Auriga integrates cutting-edge LC-MS/MS methodologies to enhance testing accuracy and efficiency:

  • Multiple Reaction Monitoring (MRM)
    MRM enhances specificity by tracking unique precursor-to-production transitions, optimizing quantification and reducing interference in complex sample matrices.
  • Stable Isotope Labeling
    This technique improves quantitative accuracy using labeled isotopes as internal standards, particularly useful in clinical and pharmaceutical quantitative analysis.

Collision-Induced Dissociation (CID)
CID generates detailed fragmentation patterns, essential for precise structural elucidation and quantification, particularly in complex, multi-component samples.

LCMS/MS

 

LCMS/MS

Accreditations and Approvals:

Auriga Research holds accreditations including NABL, FDA, and BIS, guaranteeing the highest standards of quality and regulatory compliance in LC-MS/MS testing.

LCMS/MS Analysis: Our Expertise

Pharmaceutical and Clinical Analysis

 

  • Impurity and Metabolite Profiling: Advanced profiling with LC-MS/MS supports pharmaceutical quality control, with high-precision structural elucidation and ultra-trace impurity quantification.
  • Pharmacokinetic and Biotransformation Studies: Utilizes high-resolution LC-MS/MS to assess drug biotransformation pathways and metabolite stability, essential for regulatory compliance and R&D.

Environmental and Food Safety

 

  • Multi-Residue Testing: Conducts high-specificity analysis of contaminants and pesticide residues in complex matrices, meeting rigorous regulatory and environmental standards.
  • Mycotoxin Detection: Identifies and quantifies toxic mycotoxins in food and animal feed, supporting safety compliance and reducing health risks for consumers.

At Auriga Research, we are dedicated to delivering precise, actionable insights through advanced XRD analysis, ensuring innovation and quality in your research and product development processes.

Frequently Asked Questions (FAQs)

LC-MS/MS can detect a vast range of compounds, including bioactive ingredients, impurities, metabolites, pesticides, mycotoxins, and pharmaceutical contaminants.

Auriga’s LC-MS/MS systems offer ultra-trace detection with sensitivity down to parts-per-trillion (ppt), suitable for detecting trace contaminants.

LC-MS/MS can analyze liquids, solids, and complex matrices, including biological fluids, food, environmental samples, and cosmetic products.

LC-MS/MS is optimal for non-volatile, thermally labile compounds, while GC-MS suits volatile compounds. LC-MS/MS allows more versatile, broader compound detection.

Auriga Research holds NABL, FDA, and BIS accreditations, ensuring compliance with global regulatory standards in all LC-MS/MS analyses

LC-MS/MS is widely used for pharmaceuticals, food safety, nutraceuticals, environmental, cosmetic, and veterinary testing at Auriga Research.

LC-MS/MS provides high-specificity profiling of contaminants, adhering to strict standards for safety, quality, and environmental compliance.

MRM enhances analysis specificity by tracking distinct ion transitions, optimizing quantification for complex sample matrices

LC-MS/MS generally requires minimal sample preparation, facilitating efficient, reproducible analysis while saving processing time and costs

Yes, LC-MS/MS supports pharmacokinetic profiling, identifying drug metabolites and tracking biotransformation for pharmaceutical R&D and compliance.